Researchers at Newcastle University have made what is being called a breakthrough discovery in terms of anti-aging. Specifically, the mitochondrial complex II enzyme stops working as people age. This enzyme, found in the mitochondria of cells, is necessary for keeping skin plump and smooth. The discovery that the enzyme activity decreases with age may help in the development of more effective anti-aging treatments that counteract this decline. Medical experts and live-in caregivers in Orlando may find the following information beneficial in terms of senior care.
The study, published in the Journal of Investigative Dermatology, shows for the first time that within human skin, there is a specific decrease in the activity of this important metabolic enzyme as a byproduct of the aging process. Professor Birch-Machin, who led the study, described the enzyme as a hinge between the two ways a cell makes energy and a drop in its activity. This hinge causes a reduced bio-energy in aging skin. As bio-energy decreases, damaging skin radicals increase, which leads to increased fine lines, sagging, and wrinkles. This enzyme can now be used as a specific biomarker to develop and screen anti-aging treatments.
During the study, complex II activity was monitored in 27 donors ranging in age from six to 72. Samples were taken from areas of skin protected from sun exposure to see if there was a change in activity with increasing age.
Researchers determined that enzyme activity significantly dropped with age per unit of mitochondria in cells derived from lower or dermis layers of the skin instead of the upper or epidermis layers of the skin. This is due to the amount of enzyme protein declined and the decrease was only observed in cells that stopped multiplying. Further research is necessary to understand functional consequences of the declining enzyme activity and to establish a way to assess anti-aging treatments for human skin.
Along with aiding in the development of an effective anti-aging treatment, researchers hope the findings of the study lead to improved understanding of how organs age. The data may also help develop better drugs for age-related diseases.
This breakthrough could open many doors in terms of senior health and wellness. In the meantime, seniors have other resources to turn to. Orlando Home Care Assistance is a leading provider of live-in and hourly home care that promotes longevity and wellbeing. Not only do our experienced caregivers offer housekeeping assistance to our clients, but they also help seniors maintain healthy diet, regular exercise, and social skills. Call a friendly Care Manager today at (407) 604-0506 to learn more about how your loved one can benefit from our care.